Volume 38, Number 2, April 2005
| | Methylprednisolone pulse therapy for massive lymphadenopathy in a child with intravenous immunoglobulin-resistant Kawasaki disease |
Hsin-Hsu Chen1, Po-Mai Liu1, Chin-Nam Bong2, Yu-Tsun Wu3, Kuender D. Yang1, Chih-Lu Wang1
1Department of Pediatric Allergy, Immunology and Rheumatology, Chang Gung Children's Hospital, Kaohsiung; 2Department of Pediatrics, Pingtung Christian Hospital, Pingtung; and 3Department of Pediatrics, Yunlin Huwei St. Joseph Hospital, Yunlin Hsien, Taiwan
Received: April 16, 2004 Revised:June 24, 2004 Accepted: July 1, 2004
Corresponding author: Chih-Lu Wang, MD, PhD, Department of Pediatric Allergy, Immunology and Rheumatology, Chang Gung Children¡·s Hospital, 123, Ta-Pei Road, Niaosung Hsiang, Kaohsiung 833, Taiwan. E-mail:
This e-mail address is being protected from spam bots, you need JavaScript enabled to view it
Kawasaki disease (KD) is an acute febrile multi-system vasculitis of unknown etiology. The diagnosis is based on clinical features. We describe a case of intravenous immunoglobulins (IVIG)-resistant KD presenting with persistent fever and massive cervical lymphadenopathy associated with mild respiratory distress. The symptoms resolved after methylprednisolone pulse therapy. High-dose pulse steroid may be an alternative therapeutic option in KD which presents with possible life-threatening complications or failure to respond to high-dose IVIG infusion.
Key words: Drug pulse therapy, intravenous immunoglobulins, methylprednisolone, mucocutaneous lymph node syndrome
J Microbiol Immunol Infect2005;38:149-152.
| |
|
